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The expanding cosmos of nuclear receptor coactivators

David M Lonard1, Bert W O'Malley

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Cell
|May 9, 2006
PubMed

Insights

Over 200 coactivators are crucial for gene expression regulated by nuclear receptors. These proteins integrate steroid hormone signals and are linked to diseases like cancer.

Area of Science:

  • Molecular Biology
  • Genetics
  • Endocrinology

Background:

  • Nuclear receptors are key regulators of gene expression.
  • Coactivators are essential partners for nuclear receptor function.
  • Dysregulation of coactivator activity is linked to various diseases, including cancer.

Purpose of the Study:

  • To highlight the central role of coactivators in nuclear receptor-mediated gene expression.
  • To emphasize the function of coactivators as integrators of steroid hormone signaling.
  • To underscore the implication of coactivators in disease pathogenesis.

Main Methods:

  • This study is a review of existing literature.
  • Analysis of protein-protein interactions.
  • Gene expression assays.

Main Results:

  • Approximately 200 coactivators have been identified.
  • Coactivators are diverse protein groups.
  • Coactivators mediate signals from steroid hormones.

Conclusions:

  • Coactivators are indispensable for nuclear receptor function.
  • Coactivators serve as critical signaling integrators.
  • Coactivator dysfunction is implicated in cancer and other diseases.

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