Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trimeric autotransporter adhesins: variable structure, common function.

Dirk Linke1, Tanja Riess, Ingo B Autenrieth

  • 1Max-Planck-Institut für Entwicklungsbiologie, Abteilung Proteinevolution, Spemannstr. 35, 72076 Tübingen, Germany. dirk.linke@tuebingen.mpg.de

Trends in Microbiology
|May 9, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interacting Species Database (ISDB): comprehensive resource for interspecies interactions at the molecular level.

Bioinformatics (Oxford, England)·2026
Same author

Infectious disease diagnostic competencies of medical students as a fundamental basis for physicians' resilience in addressing future infectious disease challenges.

GMS infectious diseases·2026
Same author

<i>Coxiella burnetii</i> Infection Among Blood Donors From Baden-Wuerttemberg Province and Hesse Province, Germany: A Multicentre Cross-Sectional Serological Study.

Public health challenges·2026
Same author

Diverging trends in primary and revision arthroplasty in Germany: projections and implications for healthcare delivery for the next ten years.

International orthopaedics·2026
Same author

The impact of DNA extraction methods on species quantification and apparent community composition of in vitro oral biofilms.

FEMS microbiology letters·2026
Same author

vanA-consistent phenotype vancomycin-resistant enterococcal colonization is associated with inferior overall survival in acute myeloid leukemia patients undergoing intensive chemotherapy: a single-center retrospective study.

Infection·2026
Same journal

Host membranes provide hidden gateways for 'accidental pathogens'.

Trends in microbiology·2026
Same journal

Structural inequalities in global antimicrobial resistance governance.

Trends in microbiology·2026
Same journal

Environmental microbes as modulators of plant volatile landscapes: Implications for plant-insect chemical communication.

Trends in microbiology·2026
Same journal

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools.

Trends in microbiology·2026
Same journal

Cronobacter spp.

Trends in microbiology·2026
Same journal

Anaerobic lignin deconstruction: A game changer for lignocellulosic biorefineries.

Trends in microbiology·2026
See all related articles

Trimeric autotransporter adhesins (TAAs) are key virulence factors in gram-negative bacteria. Their repetitive domain structure likely enables domain recombination, modulating host adhesion specificity across diverse hosts.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Structural Biology

Background:

  • Trimeric autotransporter adhesins (TAAs) are crucial virulence factors in gram-negative pathogens.
  • TAAs exhibit diverse host specificities, from plants to mammals, with specialized regulatory mechanisms.
  • Despite this diversity, TAAs share a conserved trimeric structure: head, stalk, and anchor.

Purpose of the Study:

  • To investigate the molecular organization of Trimeric autotransporter adhesins (TAAs).
  • To understand how the repetitive domain arrangement in TAAs influences their function.
  • To explore the role of domain recombination in modulating host adhesion specificity.

Main Methods:

  • Structural analysis of Trimeric autotransporter adhesins (TAAs).

Related Experiment Videos

  • Bioinformatic analysis of TAA domain composition and arrangement.
  • Comparative analysis of TAA structures across different pathogens and hosts.

    • Main Results:

    • TAAs consistently form trimeric surface structures with a distinct head-stalk-anchor architecture.
    • The head and stalk regions are built from a limited set of repetitively arranged domains.
    • This repetitive organization is proposed to facilitate domain recombination.

    Conclusions:

    • The simple, repetitive domain organization of TAAs is a conserved feature across diverse bacterial pathogens.
    • Domain recombination, enabled by repetitive structures, is a likely mechanism for adapting TAA host specificity.
    • Understanding TAA structure-function relationships is critical for developing novel antimicrobial strategies.