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The systemic inflammatory response syndrome.

Charles M Robertson1, Craig M Coopersmith

  • 1Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St. Louis, MO 63110, USA.

Microbes and Infection
|May 9, 2006
PubMed
Summary
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Systemic inflammatory response syndrome (SIRS) involves both pro- and anti-inflammatory processes. Understanding SIRS pathophysiology reveals potential therapeutic targets for this complex condition.

Area of Science:

  • Critical care medicine
  • Immunology
  • Pathophysiology

Background:

  • Systemic inflammatory response syndrome (SIRS) is a complex physiological response to insults.
  • SIRS involves both pro-inflammatory and anti-inflammatory pathways, challenging its definition as purely inflammatory.

Purpose of the Study:

  • To review the pathophysiology of SIRS.
  • To identify potential therapeutic targets for SIRS management.

Main Methods:

  • Literature review of SIRS pathophysiology.
  • Analysis of pro- and anti-inflammatory components in SIRS.

Main Results:

  • SIRS is characterized by a dual inflammatory response.
  • Specific pathways within SIRS present opportunities for intervention.

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Conclusions:

  • SIRS pathophysiology is multifaceted, involving opposing inflammatory actions.
  • Targeting specific components of the SIRS response may lead to novel therapies.