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Right ventricular dyssynchrony in heart failure: a tissue Doppler imaging study.
Navin Rajagopalan1, Kaoru Dohi, Marc A Simon
1Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213-2582, USA.
Journal of Cardiac Failure
|May 9, 2006
Summary
Heart failure patients show right ventricular dyssynchrony using strain imaging. This dyssynchrony is linked to pulmonary hypertension and impaired right ventricular function, indicating a poor prognosis.
Area of Science:
- Cardiology
- Cardiac Imaging
- Heart Failure Research
Background:
- Right ventricular dysfunction is a significant negative prognostic indicator in heart failure (HF).
- While left ventricular dyssynchrony is documented in HF, the presence of right ventricular dyssynchrony remains unclear.
Purpose of the Study:
- To investigate the presence of right ventricular dyssynchrony in heart failure patients.
- To assess the relationship between right ventricular dyssynchrony and other cardiac parameters.
Main Methods:
- Utilized tissue Doppler imaging to measure longitudinal strain in HF patients.
- Quantified right ventricular (RV) and left ventricular (LV) dyssynchrony based on time to peak strain differences.
- Analyzed correlations between RV dyssynchrony and pulmonary artery systolic pressure (PASP) and RV fractional area change (RVFAC).
Main Results:
- Mean RV dyssynchrony was 59 ± 45 ms and mean LV dyssynchrony was 80 ± 62 ms in 34 HF patients.
- A strong positive correlation was found between RV dyssynchrony and PASP (r = 0.73; P < .001).
- A significant negative correlation existed between RV dyssynchrony and RVFAC (r = -0.43; P < .02).
Conclusions:
- Heart failure patients demonstrate right ventricular dyssynchrony detectable by strain imaging.
- RV dyssynchrony is correlated with pulmonary hypertension and RV dysfunction in HF.
- These findings suggest RV dyssynchrony is an important factor in HF pathophysiology and prognosis.