[Application of bone morphogenetic protein (BMP) in regenerative medicine of bone]

Main purpose of bone morphogenetic protein (BMP) related research in clinical setting is the development of new efficient technologies to regenerate bone tissue effectively by utilizing BMP's osteoinductivity. Problems to be solved for that purpose are the development of efficient career system for BMP and the exploitation of methods to promote efficacy of BMP's bone forming activity. These new technologies will enable orthopaedic surgeons to replace currently used autografts with BMP combined implants. Additionally, they are also applicable for the acceleration of bone healing, treatment of non-union, spinal fusion, reconstruction of bone defects after the resection of bone tumor or arthroplasty. Thus, these new technologies are expected for the breakthrough in clinical applications of BMP.