Related Experiment Video
Updated: Aug 8, 2026

Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin
Published on: April 29, 2016
Hair follicles - a long-term reservoir for drug delivery
J Lademann1, H Richter, U F Schaefer
1Department of Dermatology and Allergy, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité-Universitatsmedizin Berlin, Berlin, Germany. Juergen.lademann@charite.de
Abstract:
Nanoparticles represent an important drug carrier system. Recently, we have reported on the penetration and storage behavior of particular and non-particular substances revealing the superiority of particular substances in the range of 300-400 nm. In this regard, it was assumed that the rigid hair shaft acts as a geared pump, moving the particles deeper into the hair follicle. In the present investigation, the storage reservoir capacity of the stratum corneum and the hair follicle infundibulum and canal are compared. Interestingly, we could demonstrate a 10 times longer storage within the hair follicles. These results underscore the importance of the hair follicle for drug delivery purposes, mainly highlighting new possibilities for the future concerning retarded delivery, application frequency, and galenic design.
More Related Videos
11:29Optical Monitoring of Living Nerve Terminal Labeling in Hair Follicle Lanceolate Endings of the Ex Vivo Mouse Ear Skin
Published on: April 5, 2016
13:04Combined Recording of Mechanically Stimulated Afferent Output and Nerve Terminal Labelling in Mouse Hair Follicle Lanceolate Endings
Published on: May 7, 2016
Related Concept Videos
Drug Distribution: Tissue Binding
For...
Multipotency and Niche of Bulge Stem Cell
Non-Oral Extravascular Drug Absorption Routes
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more effectively...
Accessory Structures of the Skin: Hair Growth and Types
Ophthalmic Drug Delivery Systems
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...