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ArteFill: a permanent skin filler
Kevin W Broder1, Steven R Cohen
1Fresh Start Craniofacial Fellow, Clinical Instructor, University of California, Division of Plastic and Reconstructive Surgery, San Diego, CA, USA. kbroder@ucsd.edu
ArteFill, a novel dermal filler combining polymethylmethacrylate microspheres and bovine collagen, offers a permanent solution for wrinkles and skin defects. Its expected FDA approval signifies a breakthrough in long-lasting cosmetic soft-tissue augmentation.
Area of Science:
- Dermatology
- Plastic Surgery
- Biomaterials Science
Background:
- The need for ideal soft-tissue fillers with long-lasting volume and resistance to degradation is unmet.
- Existing fillers often face limitations regarding resorption and biocompatibility.
- ArteFill represents a next-generation dermal filler designed to overcome these challenges.
Purpose of the Study:
- To discuss the pathophysiology, efficacy, and safety of ArteFill.
- To provide details on the injection technique for ArteFill.
- To explore the pharmacoeconomic value and market role of ArteFill.
Main Methods:
- Review of ArteFill's composition: polymethylmethacrylate microspheres in bovine collagen with lidocaine.
- Discussion of ArteFill's expected FDA approval status and market availability.
- Analysis of ArteFill's properties in relation to ideal filler characteristics.
Main Results:
- ArteFill is a permanent filler composed of polymethylmethacrylate microspheres in a collagen matrix.
- It is designed for resistance to phagocytosis and degradation, aiming for sustained volume.
- The article provides insights into its injection technique, efficacy, and safety profile.
Conclusions:
- ArteFill is poised to be the first FDA-approved permanent soft-tissue filler.
- It offers a potentially superior alternative to nonpermanent fillers for cosmetic applications.
- ArteFill is expected to play a significant role in the global dermal filler market.
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