Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testosterone and vascular reactivity.

Radu Iliescu1, Jane F Reckelhoff

  • 1Department of Physiology and Biophysics and The Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216-4505, USA.

Clinical Science (London, England : 1979)
|May 10, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conduction abnormalities after TAVI and their role in patient management: a systematic review.

Frontiers in cardiovascular medicine·2026
Same author

Building health system resilience in Romania: a consensus on policy priorities.

Journal of medicine and life·2026
Same author

CUSUM Analysis as a Predictive Tool for the Learning Curve in Left Bundle Branch Area Pacing.

Journal of clinical medicine·2026
Same author

Eco-Friendly Synthesis of Silver Nanoparticles Using <i>Lespedeza capitata</i> Extract: Antioxidant and Anti-Inflammatory Properties in Zebrafish (<i>Danio rerio</i>).

International journal of molecular sciences·2025
Same author

The Role of Mitochondrial Dysfunction and Oxidative Stress in Women's Reproductive Disorders: Implications for Polycystic Ovary Syndrome and Preeclampsia.

International journal of molecular sciences·2025
Same author

Co-Encapsulation of Multiple Antineoplastic Agents in Liposomes by Exploring Microfluidics.

International journal of molecular sciences·2025
Same journal

HDAC9 promotes atherosclerosis by suppressing CYP7A1 and impairing hepatic cholesterol excretion.

Clinical science (London, England : 1979)·2026
Same journal

Clusterin ameliorates LPS-induced ARDS by inhibiting the Wnt/β-catenin pathway.

Clinical science (London, England : 1979)·2026
Same journal

Human cytomegalovirus at the maternal-fetal interface: an overview of pathogenesis, defence, and interventions.

Clinical science (London, England : 1979)·2026
Same journal

Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.

Clinical science (London, England : 1979)·2026
Same journal

Impact of impaired branched-chain amino acid metabolism on kidney disease.

Clinical science (London, England : 1979)·2026
Same journal

Ex vivo pretreatment of donor organ with siRNA nanoparticles attenuates cold ischemia-reperfusion injury in cardiac transplantation.

Clinical science (London, England : 1979)·2026
See all related articles

Male sex hormones like testosterone have complex cardiovascular effects. While acutely beneficial, testosterone replacement impaired blood vessel function in men with androgen deficiency, highlighting potential risks.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Androgen Biology

Background:

  • Male sex hormones, particularly androgens, play a complex role in cardiovascular regulation.
  • Evidence suggests both acute vasorelaxing effects and chronic adverse impacts on blood pressure and renal function from androgens.
  • Understanding these dual effects is crucial for cardiovascular health in men.

Discussion:

  • Malkin and co-workers' study demonstrates that testosterone replacement therapy can impair vascular reactivity in men with androgen deficiency.
  • This finding contrasts with some acute effects of androgens, suggesting context-dependent cardiovascular modulation.
  • The research highlights the need to consider potential negative vascular consequences of long-term androgen administration.

Key Insights:

Related Experiment Videos

  • Testosterone replacement therapy may negatively impact vascular reactivity in hypogonadal men.
  • The chronic effects of androgens on cardiovascular function can differ significantly from their acute effects.
  • Impaired vascular reactivity is a potential adverse outcome of testosterone therapy in specific patient populations.

Outlook:

  • Further research is needed to elucidate the precise mechanisms behind testosterone's differential effects on vascular function.
  • Clinical guidelines for testosterone replacement therapy may need to incorporate assessments of vascular health.
  • Investigating personalized therapeutic strategies for androgen deficiency considering cardiovascular risk is warranted.