Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypercapnia: permissive and therapeutic.

B P Kavanagh1, J G Laffey

  • 1Department of Critical Care Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. brian.kavanagh@sickkids.ca

Minerva Anestesiologica
|May 10, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The psoas sheath block for patients requiring hip surgery: a case series.

Anaesthesia reports·2025
Same author

The effect of high-flow nasal oxygen flow rate on gas exchange in apnoeic patients: a randomised controlled trial.

Anaesthesia·2023
Same author

Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.

Intensive care medicine experimental·2021
Same author

Pre-oxygenation with facemask oxygen vs high-flow nasal oxygen vs high-flow nasal oxygen plus mouthpiece: a randomised controlled trial.

Anaesthesia·2021
Same author

Purified β-glucans from the Shiitake mushroom ameliorates antibiotic-resistant Klebsiella pneumoniae-induced pulmonary sepsis.

Letters in applied microbiology·2020
Same author

Lung-kidney cross-talk in the critically ill: insights from the Lung Safe study.

Intensive care medicine·2020

Elevated carbon dioxide levels (hypercapnia) were once avoided but are now tolerated due to lung protection strategies. Emerging research suggests hypercapnia may offer protective benefits, though its therapeutic use is still experimental.

Area of Science:

  • Critical care medicine
  • Respiratory physiology
  • Experimental physiology

Background:

  • Traditionally, hypercapnia was avoided to maintain normal physiological parameters.
  • Clinicians now tolerate permissive hypercapnia, a consequence of avoiding high tidal volumes and plateau pressures.
  • Recent research explores the dual role of elevated CO2, noting both protective and harmful effects.

Purpose of the Study:

  • To review the evolving understanding of hypercapnia in clinical practice.
  • To discuss the potential protective effects of therapeutic hypercapnia.
  • To highlight the experimental nature of current findings regarding elevated CO2.

Main Methods:

  • Review of recent clinical and experimental data on hypercapnia.
  • Analysis of the impact of tidal volumes and plateau pressures on CO2 levels.

Related Experiment Videos

  • Examination of laboratory studies investigating the effects of elevated CO2.

    • Main Results:

    • Permissive hypercapnia is increasingly accepted in clinical settings.
    • Experimental data suggest that elevated CO2 may have protective properties.
    • Some experimental situations indicate that hypercapnia can also be detrimental.

    Conclusions:

    • The role of hypercapnia in patient outcomes is complex and under investigation.
    • Therapeutic hypercapnia shows promise in experimental models.
    • Further research is needed to determine selective bedside applications for therapeutic hypercapnia.