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HPLC and 1H-NMR study of chiral recognition in some thromboxane antagonists induced by beta-cyclodextrin
A F Casy1, A D Cooper, T M Jefferies
1School of Pharmacy and Pharmacology, University of Bath, Claverton Down, UK.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1991
Abstract:
The interaction of beta-cyclodextrin with a series of structurally related chiral thromboxane antagonists was investigated using NMR and RP-HPLC. HPLC studies used both a cyclodextrin bonded phase (Cyclobond I), and beta-cyclodextrin as a mobile phase additive with an achiral C8 column. Many of the compounds exhibited chiral recognition with beta-cyclodextrin in each technique, but only partial correlations between the three data sets were observed. HPLC and ROESY NMR data suggested the possibility of bimodal inclusion.