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Nitric oxide in children with persistent asthma.

Nulma S Jentzsch1, Muriel le Bourgeois, Jacques de Blic

  • 1Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brasil.

Jornal De Pediatria
|May 10, 2006
PubMed
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Exhaled nitric oxide levels are higher in atopic asthma patients, indicating underlying inflammation despite clinical stability. This suggests atopic asthma may require closer monitoring for inflammation control.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Diagnostics

Background:

  • Asthma management often relies on clinical symptoms and lung function tests.
  • Atopic individuals exhibit heightened immune responses, potentially influencing asthma severity and treatment response.
  • Exhaled nitric oxide (FeNO) is a non-invasive biomarker of airway inflammation.

Purpose of the Study:

  • To compare exhaled nitric oxide (FeNO) levels between atopic and non-atopic asthmatic children on anti-inflammatory drugs.
  • To evaluate the correlation between FeNO measurements and standard lung function tests in pediatric asthma.

Main Methods:

  • A cross-sectional study involving 45 children (6-17 years) with persistent asthma on anti-inflammatory therapy.
  • Patients were categorized into atopic (positive skin tests) and non-atopic groups.

Related Experiment Videos

  • Concomitant assessment of clinical symptoms, lung function (FEV1, FEV1/FVC, FEF25-75%), and FeNO levels.

    • Main Results:

    • Atopic patients showed significantly higher FeNO levels (p < 0.001) and a higher frequency of eczema (p < 0.005).
    • No significant differences were observed in asthma symptoms, allergic rhinitis, food allergy, or need for systemic corticosteroids between groups.
    • Lung function parameters (FEV1, FEV1/FVC, FEF25-75%) did not significantly differ between atopic and non-atopic asthmatic children.

    Conclusions:

    • Elevated FeNO in atopic asthmatic children suggests persistent airway inflammation not fully captured by clinical or lung function assessments.
    • Clinical and functional stability in atopic asthma may mask underlying inflammation, potentially increasing relapse risk after therapy cessation.
    • FeNO measurement offers valuable insights into airway inflammation in pediatric asthma, complementing traditional diagnostic tools.