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The synthesis and antiviral activity of some 4'-thio-2'-deoxynucleoside analogues
M R Dyson1, P L Coe, R T Walker
1School of Chemistry, University of Birmingham, UK.
Nucleic Acids Symposium Series
|January 1, 1991
Abstract:
A practical 7-step synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside is described and the product has been used in the synthesis of some 4'-thio-2'-deoxynucleosides. These novel nucleoside analogues have potentially useful biological activity and are resistant to phosphorolysis.