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Direct measurement of antiviral activities by a novel immunoassay with peroxidase-labeled complement C1q
F Taguchi1, T Kawasaki, S M Lee
1Department of Microbiology, Kitasato University, School of Hygienic Sciences, Kanagawa-ken, Japan.
Journal of Clinical & Laboratory Immunology
|August 1, 1991
Abstract:
A novel immunoassay method for evaluating antiviral activities has been developed. The method involves the specific measurement of viral antigens produced in cells infected with herpes simplex virus (HSV) as a model by using the anti-HSV probe serum to detect HSV antigens and the peroxidase-labeled complement C1q to detect the immune complex formed. A new compound, heteropolyoxotungstate K7[PTi2W10O40]. 6H2O, was proven to have an anti-herpetic activity at the concentration of 5.0 micrograms/ml determined by the novel immunoassay.