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Updated: Aug 8, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

Strong physical constraints on sequence-specific target location by proteins on DNA molecules

Henrik Flyvbjerg1, Steven A Keatch, David T F Dryden

  • 1School of Chemistry, The King's Buildings, The University of Edinburgh, Edinburgh, EH9 3JJ, UK.

Nucleic Acids Research
|May 16, 2006
PubMed
Summary

Proteins binding DNA face interference from non-specific ligands. This study quantifies DNA-binding footprints and suggests linear diffusion is unlikely for target location in vivo.

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