Bacillus Calmette-Guerin, Mycobacterium bovis, as an immunomodulator in atopic diseases
Isil Barlan1, Nerin N Bahceciler, Mübeccel Akdis
1Division of Pediatric Allergy and Immunology, Marmara University Hospital, 81190 Uskudar, Istanbul, Turkey. isilbarlan@marmara.edu.tr
Abstract:
Based on the hygiene hypothesis association between atopy and bacillus Calmette-Guerin (BCG), purified protein derivative skin test reaction, mycobacterial disease, and environmental mycobacteria are summarized. The role of mycobacterial species in the activation of the innate immune response through Toll-like receptors is mentioned. The implications and perspectives of BCG as a potential therapeutic adjuvant in atopic disease are discussed.
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