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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

[The treatment of severe psoriatic arthritis with methotrexate in a weekly "mini-pulse" dosage plan]

I Parasca1, H D Boloşiu, V Rus

  • 1Clinica Medicală II, Secţia Clinica de Reumatologie, I.M.F. Cluj-Napoca.

Medicina Interna (Bucharest, Romania : 1991)
|January 1, 1991
PubMed

Insights

Methotrexate (MTX) therapy proved effective for invalidant psoriatic arthritis (PA) in a study of 18 patients. The "mini-pulse" regimen showed significant improvement in most cases, highlighting MTX as a viable treatment option.

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Context:

  • Psoriatic arthritis (PA) is a chronic inflammatory condition affecting joints and skin.
  • Invalidant PA significantly impacts patients' quality of life.
  • Limited effective long-term treatment options for severe PA exist.

Purpose:

  • To evaluate the efficacy and safety of methotrexate (MTX) therapy using a weekly "mini-pulse" regimen in patients with severe psoriatic arthritis.
  • To assess the clinical outcomes and patient response to MTX treatment for debilitating PA.

Summary:

  • A cohort of 18 patients with invalidant psoriatic arthritis received weekly "mini-pulse" methotrexate (MTX) therapy, with dosages gradually increasing up to 15 mg/week.
  • Treatment resulted in very good outcomes in 66.6% of patients, good outcomes in 16.6%, and no response in 11.1%.
  • The study highlights the positive therapeutic effects of MTX in managing severe psoriatic arthritis.

Impact:

  • Methotrexate (MTX) offers a valuable therapeutic alternative for managing severe psoriatic arthritis.
  • Correct patient surveillance and adherence to contraindications are crucial for safe and effective MTX treatment.
  • This study contributes to the understanding of MTX efficacy in rheumatological practice.

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