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Published on: October 20, 2017
LINAC radiosurgery for intracranial cavernous malformation: 10-year experience
Yin-Cheng Huang1, Chen-Kan Tseng, Cheng-Nen Chang
1Department of Neurosurgery, Chang Gung Memorial Hospital, No 5, Fu-shin St, Kweishan, Tauoyuan, Taiwan.
Clinical Neurology and Neurosurgery
|May 17, 2006
Summary
Linear accelerator (LINAC) radiosurgery is a safe option for deep or residual intracranial cavernous malformations (CM). While effectiveness for CM obliteration is unknown, it shows promise in preventing hemorrhage and seizures.
Area of Science:
- Neurosurgery
- Radiation Oncology
Background:
- Intracranial cavernous malformations (CM) have a low annual hemorrhage rate (0.23%-1.1%).
- Surgical intervention for deep symptomatic CM is controversial due to risks and low hemorrhage rates.
- Radiosurgery, particularly LINAC, is an alternative for CM treatment, especially for smaller lesions.
Purpose of the Study:
- To evaluate the safety and effectiveness of LINAC radiosurgery for treating intracranial cavernous malformations.
- To assess the outcomes of LINAC radiosurgery in patients with symptomatic or residual CM.
Main Methods:
- 30 patients with CM (hemorrhage or seizures) received LINAC radiosurgery between 1995-2005.
- Treatments involved peripheral doses from 800 cGy to 2200 cGy.
- Mean follow-up was 59.9 months; some patients received LINAC post-craniotomy for residual lesions.
Main Results:
- One patient (0.67%) re-bled post-radiosurgery.
- Two patients (6.7%) developed asymptomatic post-LINAC edema.
- All three patients with adverse events remained symptom-free during follow-up.
Conclusions:
- LINAC radiosurgery appears to be a relatively safe technique for deep or residual CM.
- Further research is needed to determine the actual effectiveness of LINAC radiosurgery for CM obliteration.
