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Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

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To what extent do the PANSS and CGI-S overlap?

Jonathan Rabinowitz¹, Angelika Mehnert, Marielle Eerdekens

¹Bar Ilan University, Ramat Gan, Israel. jr827@columbia.edu

Journal of Clinical Psychopharmacology

|May 17, 2006

Summary

The Clinical Global Impression-Severity (CGI-S) scale shows significant overlap with the Positive and Negative Symptom Scale (PANSS), indicating its utility in measuring psychotic illness severity, especially when PANSS is not feasible.

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Area of Science:

Psychiatry
Clinical Psychology
Psychopharmacology

Background:

The Positive and Negative Symptom Scale (PANSS) is the gold standard for measuring psychotic illness severity but is not always practical.
The Clinical Global Impression-Severity (CGI-S) scale is a potential alternative but requires validation against the PANSS.

Purpose of the Study:

To investigate the degree of overlap between the PANSS and CGI-S in assessing psychotic illness severity.
To determine if CGI-S can serve as a reliable measure when PANSS is not feasible.

Main Methods:

Analysis of data from 7 large antipsychotic clinical trials, including 4287 participants.
Utilized regression analysis to quantify the overlap between PANSS and CGI-S scores.
Examined agreement in detecting changes from baseline to endpoint.

Main Results:

Found a 21% to 60% overlap between PANSS and CGI-S, varying by trial and time point.
A 1-point decrease on CGI-S correlated with a 20% decline on PANSS.
Positive/disorganized symptoms and hostility/negative symptoms showed the most association with CGI-S.

Conclusions:

CGI-S and PANSS are correlated but not interchangeable measures of psychotic illness.
Both scales demonstrate substantial agreement in detecting treatment-induced changes.
CGI-S effectively overlaps with core schizophrenia symptoms, supporting its use in clinical settings.