Related Experiment Video
Updated: Aug 8, 2026
07:23
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Angiotensin-converting enzyme insertion/deletion polymorphism and retinal artery occlusion
Elke Schäfer1, Martin Weger, Tolga Birgül
1Department of Ophthalmology, Medical University Graz, Graz, Austria.
Acta Ophthalmologica Scandinavica
|May 18, 2006
Summary
The angiotensin-converting enzyme (ACE) I/D gene polymorphism is not associated with retinal artery occlusion (RAO). This study found no significant link between ACE I/D genotypes and RAO risk.
Area of Science:
- Genetics
- Cardiovascular Disease
- Ophthalmology
Background:
- The angiotensin-converting enzyme (ACE) I/D polymorphism influences ACE plasma levels and activity, impacting blood pressure regulation.
- ACE I/D gene polymorphism is a suspected risk factor for atherosclerotic vascular diseases.
Purpose of the Study:
- To investigate the potential association between the ACE I/D polymorphism and retinal artery occlusion (RAO).
Main Methods:
- A retrospective case-control study involving 159 RAO patients and 304 controls.
- ACE I/D genotypes were determined using polymerase chain reaction.
Main Results:
- No significant differences in allelic frequencies or genotype distribution of the ACE I/D polymorphism were observed between RAO patients and controls.
- Logistic regression identified arterial hypertension and current smoking as predictors of RAO, but not ACE I/D genotypes.
Conclusions:
- The ACE I/D polymorphism does not appear to be a significant risk factor for retinal artery occlusion.
