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Published on: June 16, 2019
The effect of thyroid dysfunction on N-terminal pro-B-type natriuretic peptide concentrations
Alireza M Manuchehri1, Vijay Jayagopal, Eric S Kilpatrick
1Department of Diabetes & Endocrinology, University of Hull, Hull, UK. A.Manuchehri@hull.ac.uk
Annals of Clinical Biochemistry
|May 18, 2006
Summary
Thyroid dysfunction, specifically hypothyroidism, can alter N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. However, these changes are likely insignificant due to NT-proBNP
Area of Science:
- Endocrinology and Metabolism
- Cardiovascular Diagnostics
Background:
- B-type natriuretic peptides and NT-proBNP are recognized biomarkers for diagnosing congestive heart failure.
- Previous research indicates thyroid function influences concentrations of various low molecular weight molecules.
- This study investigated the potential impact of thyroid dysfunction treatment on NT-proBNP levels.
Purpose of the Study:
- To determine if treating thyroid dysfunction (hypothyroidism and hyperthyroidism) affects NT-proBNP concentrations.
- To assess the clinical relevance of any observed changes in NT-proBNP levels.
Main Methods:
- Seventeen patients with newly diagnosed hypothyroidism and 21 with newly diagnosed hyperthyroidism were enrolled.
- NT-proBNP levels were measured at baseline and after achieving euthyroid status.
- Statistical analysis compared NT-proBNP levels between groups and before/after treatment.
Main Results:
- No significant difference in NT-proBNP was observed between hyperthyroid and hypothyroid groups pre- or post-treatment.
- A statistically significant rise in NT-proBNP was noted in the hypothyroid group after treatment (P < 0.001).
- A marginally significant fall in NT-proBNP occurred in the hyperthyroid group post-treatment (P = 0.05).
- Observed changes in NT-proBNP fell within the known wide range of biological variability.
Conclusions:
- Hypothyroidism demonstrably alters NT-proBNP concentrations.
- The magnitude of these alterations is likely masked by the inherent biological variability of natriuretic peptides.
- The observed statistically significant changes are unlikely to hold clinical relevance for diagnosis or management.
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