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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Neonatal nephrocalcinosis: long term follow up
E Porter1, A McKie, T J Beattie
1Southern General Hospital, Govan Road, Govan, Glasgow G51 4TF, Scotland, UK. lizporter1112@yahoo.co.uk
Summary
Neonatal nephrocalcinosis often resolves spontaneously by childhood. This study found no long-term renal dysfunction, suggesting prematurity may be a risk factor for hypercalciuria.
Area of Science:
- Pediatric Nephrology
- Neonatal Medicine
- Renal Physiology
Background:
- Neonatal nephrocalcinosis is a condition affecting preterm infants.
- Long-term outcomes and spontaneous resolution rates require further investigation.
Purpose of the Study:
- To evaluate the spontaneous resolution of neonatal nephrocalcinosis.
- To assess the long-term effects of neonatal nephrocalcinosis on renal function in preterm infants.
Main Methods:
- A follow-up study of 14 preterm infants with neonatal nephrocalcinosis compared to 14 matched controls at 5-7 years of age.
- Assessment included physical examination, blood pressure, renal ultrasound, and detailed urine and blood biochemistry, including glomerular filtration rate (GFR) and tubular reabsorption of phosphate (TmP/GFR).
Main Results:
- Nephrocalcinosis resolved spontaneously in 75% of cases.
- All participants achieved adequate urine osmolality; however, hypercalciuria was noted in both cases and controls.
- Glomerular filtration rate (GFR) was normal in all cases, with no significant differences in urine biochemistry between groups.
Conclusions:
- Neonatal nephrocalcinosis typically resolves spontaneously with no apparent long-term adverse effects on renal function.
- Hypercalciuria in both study and control groups suggests prematurity itself may be a risk factor.
- Further research into the implications of prematurity-associated hypercalciuria is warranted.
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