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Related Experiment Videos

FCP: functional coverage of the proteome by structures.

Ricard García-Serna1, Lulla Opatowski, Jordi Mestres

  • 1Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Institut Municipal d'Investigació Mèdica and Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain.

Bioinformatics (Oxford, England)
|May 18, 2006
PubMed
Summary

This study introduces FCP, a web tool analyzing protein structure data to assess functional coverage within protein families. It helps understand trends and biases in experimentally determined protein structures for better proteome exploration.

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Computational Biology

Background:

  • The rapid increase in experimentally determined protein structures necessitates tools for assessing proteome functional coverage.
  • Understanding the distribution and functional representation of protein structures is crucial for biological research.
  • Existing resources may not adequately capture the current state and trends of protein structure populations.

Purpose of the Study:

  • To introduce FCP, a publicly accessible web tool for analyzing protein structure data.
  • To provide insights into the functional coverage of protein families based on existing structures.
  • To identify biases in the distribution of experimentally determined protein structures.

Main Methods:

  • Development of a web-based tool (FCP) for analyzing protein structure databases.

Related Experiment Videos

  • Graphical and quantitative data presentation on functional coverage.
  • Analysis of structure distribution along functional classification schemes for enzymes and nuclear receptors.

    • Main Results:

    • FCP provides a comprehensive overview of the current state and trends in protein structure populations.
    • The tool reveals the degree of functional coverage for enzymes and nuclear receptors.
    • Analysis highlights biases in the distribution of structures within protein families.

    Conclusions:

    • FCP serves as a valuable resource for researchers studying protein structure-function relationships.
    • The tool aids in identifying gaps in structural coverage and guiding future experimental efforts.
    • FCP facilitates a deeper understanding of the proteome's structural landscape and functional diversity.