Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improving reliability and performance of DNA microarrays.

Maria Sievertzon1, Peter Nilsson, Joakim Lundeberg

  • 1Royal Institute of Technology, AlbaNova University Center, KTH Genome Center, Department of Biotechnology, S-106 91 Stockholm, Sweden. maria.sievertzon@biotech.kth.se

Expert Review of Molecular Diagnostics
|May 19, 2006
PubMed
Summary

This review covers gene expression analysis using microarray technology, focusing on reliability and performance issues of GeneChips and spotted microarrays. It also briefly touches on recent advances and new applications in the field.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration.

Nature neuroscience·2026
Same author

Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve.

Nature communications·2026
Same author

Single-cell spatial multi-omics molecular pathology enabled by SuperFocus.

bioRxiv : the preprint server for biology·2026
Same author

Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy-Naïve Localized Prostate Cancer.

Cancer research·2026
Same author

Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response.

Research square·2026
Same author

Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies.

Nature communications·2026

Area of Science:

  • Biotechnology
  • Genomics
  • Molecular Biology

Background:

  • Microarray technology has numerous platforms and versions, each with distinct characteristics and applications.
  • Gene expression analysis is a critical area in molecular biology and genomics research.

Purpose of the Study:

  • To review key issues in reliability and performance of commonly used microarray platforms for gene expression analysis.
  • To provide an overview of recent advances and new applications in microarray technology.

Main Methods:

  • Comparative analysis of in situ-synthesized oligonucleotide microarrays (GeneChips) and spotted microarrays.
  • Literature review of existing studies on microarray reliability and performance.

Main Results:

Related Experiment Videos

  • Identified key challenges and considerations for ensuring reliable and high-performance gene expression data from both GeneChips and spotted microarrays.
  • Highlighted specific areas where each platform excels or faces limitations.

Conclusions:

  • Understanding the nuances of different microarray platforms is crucial for accurate gene expression analysis.
  • Ongoing advancements continue to expand the utility and applications of microarray technology in biological research.