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Related Experiment Videos

High sensitivity C-reactive protein in asthma.

M Takemura1, H Matsumoto, A Niimi

  • 1Dept of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.

The European Respiratory Journal
|May 19, 2006
PubMed
Summary

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High-sensitivity C-reactive protein (hs-CRP) levels are elevated in steroid-naive asthma patients, correlating with reduced lung function and increased airway inflammation. hs-CRP may indicate inflammation in asthma.

Area of Science:

  • Pulmonary Medicine
  • Clinical Immunology

Background:

  • Asthma involves chronic airway inflammation.
  • High-sensitivity C-reactive protein (hs-CRP) is a marker for systemic inflammation.
  • The role of hs-CRP in asthma requires further investigation.

Purpose of the Study:

  • To assess serum hs-CRP levels in asthma patients.
  • To explore the relationship between hs-CRP and asthma clinical characteristics.
  • To determine if hs-CRP correlates with airway inflammation.

Main Methods:

  • Cross-sectional study of steroid-naive asthma patients, inhaled corticosteroid-treated asthma patients, and healthy controls.
  • Serum hs-CRP levels were measured using high-sensitivity assays.
  • Pulmonary function tests and sputum eosinophil counts were assessed.

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Main Results:

  • Steroid-naive asthma patients had significantly higher hs-CRP levels than controls.
  • No significant difference in hs-CRP was observed in patients on inhaled corticosteroids.
  • In steroid-naive patients, hs-CRP negatively correlated with pulmonary function and positively with sputum eosinophils.

Conclusions:

  • Elevated hs-CRP may be linked to airflow obstruction and airway inflammation in asthma.
  • hs-CRP could potentially serve as a surrogate marker for airway inflammation in asthma.
  • The association between hs-CRP and asthma parameters is diminished by inhaled corticosteroid treatment.