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Updated: Aug 8, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
An in-vitro test set-up for evaluation of a voice-producing element under physiologic acoustic conditions
Arjan van der Plaats1, Harm K Schutte, Frits J M van der Eerden
1Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abstract:
To improve the voice quality of laryngectomised patients, a voice-producing element has been developed. Prior to in vivo testing we constructed and validated an in-vitro test set-up, consisting of a physical model of the subglottal tract and three physical models of the vocal tract, for the vowels /a/, /i/ and /u/ to evaluate the voice-producing element under physiologic acoustic conditions. To meet acoustic conditions described in the literature, we determined the appropriate dimensions of these physical models, using a numerical model of the pressure perturbation in rigid tubes. The numerical model showed that an acoustic equivalent of the subglottal tract could be obtained with a three-tube system and an end impedance. Vocal tract models could be constructed using two- and four-resonator tubes. The physical models were built and successfully validated according to the human acoustic properties. The developed in-vitro set-up can now be applied to test voice-producing elements or vocal fold models under physiologic acoustic conditions.
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