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Related Experiment Videos

Capsaicin-resistant arterial baroreceptors.

Patrick J Reynolds1, Wei Fan, Michael C Andresen

  • 1Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239-3098, USA. pjreynolds@msn.com

Journal of Negative Results in Biomedicine
|May 20, 2006
PubMed
Summary

Functional TRPV1 channels are present in C-type but not A-type aortic baroreceptors. Capsaicin (CAP) affects C-type baroreceptors, but high concentrations have non-specific actions.

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Area of Science:

  • Neuroscience
  • Physiology

Background:

  • Aortic baroreceptors (BRs) are mechanoreceptors crucial for cardiovascular autonomic reflexes.
  • They possess either lightly myelinated (A-type) or non-myelinated (C-type) axons, similar to spinal afferent neurons.

Purpose of the Study:

  • To investigate the presence and function of vanilloid receptor TRPV1 in peripheral aortic BRs.
  • To determine if TRPV1 agonists capsaicin (CAP) and resiniferatoxin (RTX) alter BR pressure-discharge properties.

Main Methods:

  • Whole nerve recordings of compound action potentials from the aortic depressor nerve.
  • Single-fiber recordings in an aortic arch-aortic nerve preparation.
  • Periaxonal and intralumenal application of CAP and RTX.

Main Results:

  • CAP application decreased C-wave amplitude and eliminated it at higher concentrations, suggesting TRPV1 presence on C-type BR axons.
  • CAP inhibited discharge of C-type BRs but had no effect on A-type BRs at low concentrations.
  • High CAP concentrations showed non-specific inhibitory actions on A-type BRs.
  • RTX did not affect regularly discharging (A-type) BRs.
  • CAP-sensitive BRs exhibited lower discharge regularity.

Conclusions:

  • Functional TRPV1 channels are present in C-type aortic arch baroreceptors, but not in A-type (A-delta) myelinated BRs.
  • CAP exhibits non-specific inhibitory actions at high concentrations, distinct from TRPV1 binding.
  • Caution is advised when using high concentrations of CAP due to potential non-specific effects.

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