Prolonged mechanical systole and increased arterial wave reflections in diastolic dysfunction
T Weber1, J Auer, M F O'Rourke
1Cardiology Department, Klinikum Kreuzschwestern, Wels, Austria. thomas.weber@klinikum-wels.at
Heart (British Cardiac Society)
|May 20, 2006
Summary
Left ventricular ejection time indexed for heart rate (LVETI) and augmented pressure (AP) were found to be elevated in patients with diastolic dysfunction (DD). These non-invasive measurements may help in diagnosing DD.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Diastolic dysfunction (DD) is a significant clinical condition affecting cardiac function.
- Accurate and non-invasive diagnostic methods for DD are crucial for timely management.
Purpose of the Study:
- To investigate if left ventricular ejection time indexed for heart rate (LVETI) and augmented pressure (AP) are elevated in patients with diastolic dysfunction (DD).
- To assess the potential of LVETI and AP as non-invasive markers for DD.
Main Methods:
- A prospective observational study involving 235 patients undergoing left heart catheterization.
- Patients were categorized into definite DD, possible DD, or no DD (controls) based on established criteria.
- LVETI and AP were measured non-invasively using radial applanation tonometry; echocardiography was also performed.
Main Results:
- Patients with definite DD exhibited significantly longer LVETI and higher AP compared to those with possible DD and controls (p < 0.000001 for both).
- Receiver operating characteristic curve analysis showed LVETI had diagnostic capability for DD, comparable to echocardiography (E:E').
- LVETI provided independent predictive power for DD when added to clinical and echocardiographic variables.
Conclusions:
- Mechanical systole is prolonged, and arterial wave reflections are increased in patients with DD.
- Rapid, non-invasive assessment of LVETI and AP may assist in the confirmation or exclusion of diastolic dysfunction.
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