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Related Concept Videos

Lipid Digestion01:06

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

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Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

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Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

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Lipid Absorption01:24

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Blood Studies for Cardiovascular System III: Serum Lipid Profile

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues.

Kaori Minehira-Castelli1, Scott W Leonard, Quinn M Walker

  • 1Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA.

Journal of Lipid Research
|May 20, 2006
PubMed
Summary
This summary is machine-generated.

Very low VLDL secretion does not impact peripheral tissue alpha-tocopherol levels. This study shows that VLDL is not essential for delivering this important antioxidant to tissues.

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Area of Science:

  • Biochemistry
  • Nutritional Science
  • Cell Biology

Background:

  • Alpha-tocopherol (Vitamin E) is a vital lipid-soluble antioxidant.
  • It protects cellular lipids from oxidative damage.
  • Hepatic uptake and presumed VLDL secretion are key to its distribution.

Purpose of the Study:

  • To investigate the role of VLDL secretion in alpha-tocopherol delivery to peripheral tissues.
  • To determine if VLDL is essential for distributing alpha-tocopherol.

Main Methods:

  • Utilized genetically modified mice lacking liver microsomal triglyceride transfer protein (Mttp).
  • These Mttp(Delta/Delta) mice cannot secrete VLDL.
  • Measured alpha-tocopherol levels in plasma, liver, and peripheral tissues.

Main Results:

  • Mice lacking VLDL secretion had lower plasma and higher liver alpha-tocopherol.
  • Peripheral tissue alpha-tocopherol levels were similar to control mice.
  • Deuterated alpha-tocopherol incorporation was comparable between groups.

Conclusions:

  • VLDL secretion is not critical for delivering alpha-tocopherol to peripheral tissues.
  • The absence of VLDL has minimal impact on peripheral alpha-tocopherol stores in mice.
  • Alternative pathways likely facilitate alpha-tocopherol distribution.