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Updated: Aug 11, 2026

Analysis of SCAP N-glycosylation and Trafficking in Human Cells
Published on: November 8, 2016
Emerging roles of CREST superfamily members in lipid metabolism
Takuma Takagaki1, Tomoyoshi Shingaki1, Nozomu Kono1
1Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan.
Abstract:
CREST superfamily members are a series of multi-transmembrane proteins conserved across a wide range of species. There are approximately 20 members in mammals. CREST superfamily members have been assigned various functions, including those of receptors, transporters, enzymes, and membrane fusion factors. Recent functional and structural analyses of CREST superfamily members have revealed that all members possess a structure resembling an enzymatic active site that catalyzes hydrolysis reactions. Furthermore, it is becoming increasingly clear that they interact with various membrane lipids and are involved in lipid metabolism. This review summarizes current knowledge of the structure and function of each CREST superfamily member and explores their potential as lipid-metabolizing enzymes.
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