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Related Experiment Videos

Mast cell tryptase in postmortem serum-reference values and confounders.

Erik Edston1, Olle Eriksson, Marianne van Hage

  • 1Institution for Clinical and Molecular Medicine, Linköping University, Linköping 581 85, Sweden. eried@imk.liu.se

International Journal of Legal Medicine
|May 20, 2006
PubMed
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Mast cell tryptase levels increase in cases of asphyxia and anaphylaxis. Postmortem tryptase measurements are recommended in femoral blood, with an upper normal limit of 44.3 microg/l.

Area of Science:

  • Forensic Pathology
  • Biochemistry

Background:

  • Mast cell tryptase is a marker for anaphylaxis.
  • Factors like sampling site and postmortem conditions can affect tryptase levels.

Purpose of the Study:

  • To investigate factors influencing tryptase concentrations in postmortem blood.
  • To establish normal tryptase limits for forensic interpretation.

Main Methods:

  • Tryptase was measured in femoral and heart blood from 60 deaths (controls, asphyxia, anaphylaxis).
  • Commercial FEIA method used for alpha- and beta-tryptase analysis.
  • Statistical analysis to determine normal limits and significant differences.

Main Results:

  • Anaphylactic deaths showed significantly elevated femoral blood tryptase.

Related Experiment Videos

  • Asphyxia cases also had elevated femoral blood tryptase compared to controls.
  • Femoral blood tryptase was not affected by body position or resuscitation efforts.

    • Conclusions:

    • Premortem asphyxia can elevate tryptase concentrations.
    • Postmortem tryptase measurements should be performed on femoral blood.
    • The upper normal limit for femoral blood tryptase is 44.3 microg/l.