[Synthesis of thiophene and alpha-terthiophene derivatives with antiproliferative activity]
Zsolt Székelyhidi1, János Pató, Bálint Hegymegi-Barakonyi
1Semmelweis Egyetem, Kooperációs Kutató Központ, Budapest.
Abstract:
We have synthesised a series of known alpha-terthiophene lead molecules with PKC (protein kinase C) inhibitory activity and the compounds were tested in cell proliferation assay on EGF-RTK (epidermal growth factor receptor protein tyrosine kinase) over-expressing tumour cell line (A431). We found that two of them had excellent antiproliferative activity. We prepared a focused molecule library around the thiophene and the terthiophene scaffold and examined these compounds in cell proliferation assay on A431.
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