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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
[Studies on flavonoids of Andrographis paniculata]
Li-xia Chen1, Ge-xia Qu, Feng Qiu
1Shenyang Pharmaceutical University, China.
Summary
This study isolated twelve flavonoids from Andrographis paniculata. Compound 6 is a new natural product, while compounds 8, 11, and 12 are newly identified in this Andrographis species.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
Context:
- Andrographis paniculata is a medicinal plant with a history of traditional use.
- Flavonoids are a diverse group of plant secondary metabolites with various biological activities.
Purpose:
- To isolate and identify flavonoids from the aerial parts of Andrographis paniculata.
- To characterize novel and previously unreported flavonoids from this species.
Summary:
- Twelve flavonoids were isolated from an 85% ethanol extract of Andrographis paniculata using advanced chromatographic techniques.
- Structures were elucidated through spectral analysis and chemical evidence.
- Compound 6 (5,4'-dihydroxy-7,8,2',3'-tetramethoxyflavone) is a new naturally occurring product.
- Compounds 8 (5,7,8-trimethoxydihydroflavone), 11 (5,7,4'-trihydroxyflavone), and 12 (5,7,3',4'-tetrahydroxyflavone) were identified for the first time in the Andrographis genus.
Impact:
- Expands the known phytochemical profile of Andrographis paniculata.
- Provides new chemical entities for further pharmacological investigation.
- Contributes to the understanding of flavonoid diversity in medicinal plants.
