Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging and innate immunity.

Rafael Solana1, Graham Pawelec, Raquel Tarazona

  • 1Department of Cellular Biology, Physiology, and Immunology, University of Córdoba, E-14004 Córdoba, Spain. rsolana@uco.es

Immunity
|May 23, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune aging biomarkers for clinical trials.

Nature medicine·2026
Same author

Immunosenescence and cytomegalovirus-associated immune signatures on severe acute respiratory syndrome coronavirus 2 booster responses.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

Comparing fourteen consensus biomarkers of aging: epigenetic pace of aging as the strongest predictor of mortality in BASE-II.

Biomarker research·2026
Same author

Vδ1 T-cell subset appears to be responsive to PD-1 blockade therapy and is associated with survival in melanoma.

Journal for immunotherapy of cancer·2026
Same author

Aging-associated immune signature as a predictor of mortality in end-stage renal disease: results from the longitudinal iESRD study.

Immunity & ageing : I & A·2025
Same author

Open problems in ageing science: a roadmap for biogerontology.

GeroScience·2025
Same journal

Targeting cholesterol esterification sensitizes liver cancer to CD8<sup>+</sup> T cell attack by impairing metabolic and redox resilience.

Immunity·2026
Same journal

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same journal

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.

Immunity·2026
Same journal

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection.

Immunity·2026
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
See all related articles

Aging significantly impairs both adaptive and innate immunity, posing a major health challenge for older adults. Understanding these immune system changes is crucial for improving health and longevity in the elderly population.

Area of Science:

  • Immunology
  • Gerontology
  • Aging Research

Background:

  • Adaptive immunity declines significantly with advanced age, contributing to health issues in the elderly.
  • Recent evidence highlights that aging profoundly impacts innate immunity, affecting older adults' health and longevity.

Discussion:

  • The deterioration of adaptive immunity is a well-established consequence of aging.
  • The impact of aging on innate immunity is increasingly recognized as a critical factor in geriatric health.

Key Insights:

  • Aging affects both adaptive and innate immune systems.
  • Innate immune system decline in aging is a significant contributor to health problems in older individuals.

Outlook:

  • Further research into age-related immune system changes can inform interventions.

Related Experiment Videos

  • Targeting innate immune pathways may offer new strategies to enhance health and longevity in the elderly.