Related Experiment Video
Updated: Jan 6, 2026
10:08
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
Published on: May 18, 2022
3.9K
Open problems in ageing science: a roadmap for biogerontology
Angelo Talay1, Aleksey V Belikov1, Paul Ka Po To1
1Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Geroscience
|November 8, 2025
Summary
This study compiles 100 open questions in ageing and longevity science, identified through community input and NLP analysis. It highlights key research gaps and emerging areas to guide future biogerontology research.
Area of Science:
- Biogerontology
- Longevity Science
- Aging Research
Background:
- Significant advancements in aging science have been made.
- Numerous fundamental questions in aging and longevity remain unanswered.
Purpose of the Study:
- To present a curated list of 100 open problems in aging and longevity science.
- To identify well-established and emerging research gaps.
Main Methods:
- Community engagement to collect research questions.
- Natural Language Processing (NLP) analysis to assess literature prevalence.
- Categorization of questions into key research topics.
Main Results:
- A comprehensive list of 100 open problems in aging and longevity science.
- Identification of research gaps across molecular, cellular, comparative biology, biomarkers, and therapeutics.
- Categorization into molecular/cellular mechanisms, model organisms, biomarkers, and interventions.
Conclusions:
- The compilation offers a roadmap for future biogerontology research.
- Highlights current key research questions in aging biology.
- Facilitates progress in the field of aging and longevity.
Related Concept Videos
01:26Aging
552
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
552
01:19The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
172
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
172
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
201
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
201
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
176
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
176
01:37Mitochondria
19.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.4K