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Glucose partition coefficient and diffusivity in the lower skin layers.

Enam Khalil¹, Kosmas Kretsos, Gerald B Kasting

¹Faculty of Pharmacy, The University of Jordan, Amman, 11942, Jordan. ekayoub@ju.edu.jo

Pharmaceutical Research

|May 23, 2006

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This study quantifies glucose diffusion and partitioning in human skin layers. Glucose diffusivity is lower in dermis and significantly lower in viable epidermis than in water.

Area of Science:

Dermatology
Biophysics
Pharmacokinetics

Background:

Understanding glucose transport in skin is crucial for drug delivery and diabetes research.
The skin acts as a barrier, influencing the absorption and distribution of molecules like glucose.

Purpose of the Study:

To estimate the diffusivity and partitioning of glucose in human dermis and viable epidermis.
To quantify glucose transport parameters within different skin layers.

Main Methods:

In vitro measurement of glucose partition coefficients in dermis, epidermis (TSE), stratum corneum (SC), and split-thickness skin (TSS) using human cadaver skin.
Determination of glucose permeability across dermis and TSS using side-by-side diffusion cells.
Measurement of glucose desorption from TSE and human epidermal membrane (HEM) at 32°C.

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Main Results:

Glucose partition coefficients were below unity for all skin layers, suggesting excluded volumes.
Dermal glucose diffusivity was calculated as 2.64 x 10(-6) cm²/s, about one-third of its value in water.
Estimated glucose diffusivities in viable epidermis were substantially lower, ranging from 0.037 to 1.0 x 10(-6) cm²/s.

Conclusions:

Glucose partitioning in skin layers is limited by excluded volumes.
Hindered glucose diffusion in the dermis is attributed to the tissue's structural components.
Viable epidermis exhibits significantly reduced glucose diffusivity compared to dermis and water.