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Solid-state characterization of buspirone hydrochloride polymorphs
M Sheikhzadeh1, S Rohani, A Jutan
1Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada.
Pharmaceutical Research
|May 23, 2006
Summary
This study characterized two forms of buspirone hydrochloride, an anxiolytic drug. Techniques like microscopy, thermal analysis, FTIR, and XRPD differentiated the crystalline forms, aiding in quality control.
Area of Science:
- Solid-state chemistry
- Pharmaceutical analysis
- Materials science
Background:
- Buspirone hydrochloride is an anxiolytic medication.
- Understanding its polymorphic forms (Form 1 and Form 2) is crucial for pharmaceutical development and quality control.
Purpose of the Study:
- To comprehensively characterize Form 1 and Form 2 of buspirone hydrochloride.
- To evaluate various analytical techniques for distinguishing and quantifying these polymorphic forms.
Main Methods:
- Microscopy (optical, hot stage, scanning electron microscopy)
- Thermal analysis (differential scanning calorimetry, thermogravimetric analysis)
- Spectroscopy (FTIR, Raman)
- X-ray powder diffractometry (XRPD)
Main Results:
- Form 1 exhibited plate crystals, while Form 2 showed columnar crystals, both with good filterability.
- The two forms were found to be enantiotropic.
- FTIR and Raman spectroscopy effectively differentiated the polymorphs, with XRPD proving useful for both qualitative and quantitative analysis.
Conclusions:
- Multiple analytical techniques can successfully characterize buspirone hydrochloride polymorphs.
- XRPD is a powerful tool for polymorphic identification and quantification.
- This characterization aids in ensuring the quality and consistency of buspirone hydrochloride formulations.
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