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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Selective DNA strand scission with binuclear copper complexes: implications for an active Cu2-O2 species

Sunita Thyagarajan1, Narasimha N Murthy, Amy A Narducci Sarjeant

  • 1Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.

Journal of the American Chemical Society
|May 25, 2006
PubMed
Summary

Binuclear copper(II) complexes selectively cleave DNA at specific sites. The N4 and N5 copper complexes, in the presence of 3-mercaptopropanoic acid and oxygen, demonstrate significant DNA strand scission activity.

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