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Updated: Aug 8, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
Exploring the neural organization of person-related knowledge: lateralization of lesion, category specificity, and
Natalie A Lambert1, Michelle A Swain, Laurie A Miller
1School of Psychology, University of Sydney, Department of Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Abstract:
While it is generally agreed that the right fusiform gyrus is specialized for face recognition, the question of whether knowledge about persons is lateralized in the temporal lobes is more contentious. Does knowledge about people differ from other kinds of object knowledge with respect to brain laterality? Are side-of-lesion effects mediated by stimulus modality? This study aimed to investigate these questions by comparing patients with left temporal (LT) (n=8) and right temporal (RT) (n=11) lesions to control subjects (n=12) on verbal and visual tests of people, buildings, and objects. The RT group was impaired at recognizing famous faces, but not at choosing the picture of a famous building or a famous name from nonfamous distracters. The LT group was impaired at naming people, buildings, and objects, regardless of stimulus modality. When presemantic processing was controlled for, neither patient group was impaired in producing person-specific knowledge to faces or names, supporting the notion that semantic knowledge for people as for other kinds of objects, is stored in a distributed network across both hemispheres, regardless of stimulus modality.
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