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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

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Published on: June 10, 2017

The molecular mechanisms of classic Hodgkin's lymphoma

Rachael S Felberbaum1

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA. rachael.felberbaum@yale.edu

The Yale Journal of Biology and Medicine
|May 25, 2006
PubMed

Classic Hodgkin's lymphoma is characterized by the appearance of giant abnormal cells called Hodgkin and Reed-Sternberg (HRS) cells. HRS cells arise from germinal center B lymphocytes and in about 50 percent of patients, are infected with Epstein-Barr Virus. In addition, HRS cells show constitutive NF-kappaB activation and are resistant to apoptosis. This paper reviews several recent studies that for the first time implicate specific molecules in the pathogenesis of classic Hodgkin's lymphoma. Targeting these molecules could lead to the development of novel therapies for this disease.

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