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Psammomatous choroid plexus papilloma: three cases with atypical characteristics
Martha Lilia Tena-Suck1, Mario López-Gómez, Citlaltepelt Salinas-Lara
1Departament of Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico 14269. tenasuck@yahoo.com
Background:
Intravertricular papillary neoplasms are derived from choroid plexus epithelium. Although choroid plexus tumors account for 0.4% to 0.6% of all brain tumors, they represent 2% to 4%. Approximately 80% of choroid plexus carcinomas arise in children.
Cases Description:
We describe 3 cases of choroid plexus papilloma (CPP) with profuse psammomatous bodies and calcifications that have lost their normal papillary architecture. Immunohistochemistry was positive for glial fibrillary acidic protein in 2 cases, and proliferating cellular nuclear antigen index was higher compared with regular CPPs. All 3 patients were female and were 12, 40, and 48 years old, respectively.
Conclusion:
We describe psammomatous CPPs and suggest a difference from CPPs because of the more aggressive clinical course, and higher nuclear proliferation index (proliferating cellular nuclear antigen) than the CPPs that lack psammoma bodies.
