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Topical calcipotriol treatment in advanced breast cancer
M Bower1, K W Colston, R C Stein
1Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London.
Abstract:
19 patients with locally advanced or cutaneous metastatic breast cancer were treated with the topical vitamin D analogue calcipotriol 100 micrograms daily. 14 patients completed 6 weeks' treatment; 3 showed a 50% reduction in the bidimensional diameter of treated lesions and 1 other patient showed a minimal response. 2 patients became hypercalcaemic during treatment. In all patients who responded the tumours contained receptors for 1,25-dihydroxyvitamin D3, shown by immunocytochemistry.
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