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Dopaminergic mechanisms controlling urethral function in rats.

Teruyuki Ogawa1, Satoshi Seki, Hitoshi Masuda

  • 1Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

Neurourology and Urodynamics
|May 25, 2006
PubMed
Summary

Activation of D2-like dopamine receptors suppresses urethral sphincter activity, potentially worsening urge incontinence in Parkinson's disease patients. This study explored dopamine receptor subtypes

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Area of Science:

  • Neuroscience
  • Urology
  • Pharmacology

Background:

  • Dopamine plays a crucial role in regulating various physiological functions.
  • Understanding dopamine receptor subtype involvement in urethral activity is essential for managing lower urinary tract symptoms.

Purpose of the Study:

  • To investigate the role of dopamine receptor subtypes in the control of urethral activity.
  • To determine the effects of D1- and D2-like dopamine receptor agonists and antagonists on urethral pressure and sphincter activity.

Main Methods:

  • Simultaneous recordings of intravesical and urethral perfusion pressure (UPP) were performed in rats under anesthesia.
  • Intravenous (i.v.), intrathecal (i.t.), or intracerebroventricular (i.c.v.) administration of dopamine D1-like (SKF38393) and D2-like (quinpirole) receptor agonists, and their respective antagonists (SCH23390 and remoxipride) were used.

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  • Changes in coordinated activity of the bladder and urethral sphincter were examined.

    • Main Results:

    • Quinpirole (D2-like agonist) dose-dependently decreased baseline urethral pressure via i.v. and i.c.v. administration, indicating supraspinal D2 receptor involvement.
    • SCH23390 (D1-like antagonist) dose-dependently decreased high-frequency oscillations (HFO) of the urethral sphincter.
    • SKF38393 (D1-like agonist) and remoxipride (D2-like antagonist) showed no significant effects on bladder or urethral activity.

    Conclusions:

    • Activation of D2-like dopamine receptors at a supraspinal level suppresses striated muscle urethral sphincter activity.
    • This D2 receptor-mediated decrease in urethral resistance may exacerbate urge incontinence symptoms, particularly in patients with Parkinson's disease.