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[Study on preparation of beta-cyclodextrin inclusion compound for borneolumsyntheticum from Huoxuezhitong capsules]
Zhi-Yu Guan1, Cun-Hai Pu, Kai-Jun Zhao
1Nanjing ZhongShan Pharmaceutical Factory Technology Center, Nanjing 210012, China.
Objective:
To study the optimum inclusion process of clolloid mill for borneolumsyntheticum from Huoxuezhitong Capsules.
Methods:
The study was carried out with orthogonal design. The borneol content in inclusion complex, the utilization ratio of borneol, and synthesis grading were used as evaluating indicator to review the effects of 3 factors, including the proportion of borneolumsyntheticum to beta-cyclodextrin (mol: mol), milling time and water addition.
Results:
The optimum process were borneolumsyntheticum: beta-cyclodextrin was 1:1, the milling time was 40 min, water addition was double.
Conclusion:
The optimum process is feasible, and fit for industrial production, with the advantage of high utilization ratio, shot time and low energy consumption.
