Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pancreatic development and stem cell-based regenerative medicine].

Shoen Kume1, Nobuaki Shiraki

  • 1Division of Stem Cell Biology, Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto 860-0811.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|May 26, 2006
PubMed
Summary

This study reviews pancreas development, focusing on isolating pancreatic stem cells and growing functional beta cells from embryonic stem cells for regenerative medicine. It explores endodermal induction and organogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Initial Symptom Duration Among Vulnerable Dialysis Patients Hospitalized for Long-Term Care Correlates With Post-COVID-19 Poor Prognosis.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·2026
Same author

Partial reduction of sympathetic noradrenaline synthesis enhanced insulin secretion and cell-cycle-associated activity of pancreatic β cells in mice.

American journal of physiology. Cell physiology·2026
Same author

Zinc dynamics in the pluripotent stem cells during maintenance of pluripotency and pancreatic differentiation.

Scientific reports·2026
Same author

Small Intestine-Permeable Cyclic Peptide-Based Technology Enables Efficient Oral Delivery and Glycemic Efficacy of Zinc-Stabilized Insulin Hexamer and Its Analogs in Diabetic Mice.

Molecular pharmaceutics·2025
Same author

Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulation.

EBioMedicine·2025
Same author

Editorial - Advances in cell, tissue, organ engineering, and organoid technology.

European journal of cell biology·2025

Area of Science:

  • Developmental biology
  • Stem cell research
  • Endocrinology

Context:

  • Pancreas development is initiated by notochord signals to the embryonic gut endoderm.
  • Pancreatic gene pdx1 expression marks early pancreas development.
  • Cell lineage studies suggest a common pancreatic stem cell differentiates into exocrine and endocrine progenitors.

Purpose:

  • To review pancreas development and regeneration.
  • To isolate pancreatic stem cells.
  • To develop functional pancreatic endocrine beta cells in culture using embryonic stem (ES) cells.

Summary:

  • The pancreas arises from embryonic gut epithelium via inductive signals, with pdx1 as an early marker.
  • A common pancreatic stem cell is proposed to generate exocrine and endocrine progenitors.

Related Experiment Videos

  • Research focuses on understanding pancreas organogenesis and developing beta cells from ES cells.

    • Impact:

    • Provides insights into pancreas development and potential therapeutic strategies.
    • Highlights the use of ES cells for generating pancreatic cells.
    • Contributes to the field of regenerative medicine for diabetes treatment.