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Nomen est Omen: do antidepressants increase p11 or S100A10?
1The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA. hmanev@psych.uic.edu.
Journal of Biomedical Discovery and Collaboration
|May 26, 2006
Summary
The protein S100A10, also known as p11, is increasingly recognized for its role in depression and antidepressant action. Its elevated brain expression suggests a common mechanism for antidepressants involving S100 proteins.
Area of Science:
- Neurobiology
- Molecular Psychiatry
- Biochemistry
Background:
- Multiple names for the same gene/protein can hinder research across disciplines.
- The protein p11, also known as S100A10, has emerged as a potential key player in depression and antidepressant mechanisms.
Purpose of the Study:
- To highlight the significance of S100A10 (p11) in neurobiological research related to depression.
- To explore the potential commonalities and interactions of S100 proteins in antidepressant action.
Main Methods:
- Review of recent findings on S100A10 expression in antidepressant-treated mice.
- Comparison of S100A10 expression patterns with other S100 proteins, such as S100B.
- Analysis of cell-specific expression of S100A10 and S100B in the brain.
Main Results:
- Antidepressant treatment increased S100A10 expression in the mouse brain.
- Antidepressant treatment also increases brain content of another S100 protein, S100B.
- S100A10 and S100B exhibit distinct cellular localization (neurons vs. glia) and may have opposing regulatory roles.
Conclusions:
- Upregulation of S100 proteins in the brain may be a shared feature of antidepressant action.
- Interplay between different S100 proteins could determine the cell and region specificity of antidepressant effects.
- Consistent use of the name S100A10 may encourage broader research participation in this neurobiological area.