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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
Published on: May 16, 2019
Wound problems due to zinc deficiency
Girish K Patel1, Keith G Harding
1Department of Dermatology and Wound Healing Research Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK. patelgk@cf.ac.uk
Insights
Zinc deficiency can cause diarrhea, dermatitis, and disinterest. Prompt zinc supplementation rapidly improved symptoms in a pediatric patient with a history of gastrointestinal surgery.
Area of Science:
- Pediatric Gastroenterology
- Nutritional Deficiencies
Background:
- Zinc deficiency is uncommon but can manifest in clinical practice.
- Previous gastrointestinal surgery can increase the risk of nutritional deficiencies.
Observation:
- A 4.5-year-old boy with a history of gastrointestinal surgery presented with diarrhea, disinterest, and dermatitis.
- Clinical presentation suggested a potential zinc deficiency.
Findings:
- Low serum zinc levels confirmed the diagnosis of zinc deficiency.
- Parenteral zinc administration resulted in rapid clinical improvement of all symptoms.
- Normalizing zinc levels was crucial before subsequent surgical procedures.
Implications:
- Highlights the importance of considering zinc deficiency in patients with gastrointestinal issues.
- Underscores the link between zinc status and wound healing, necessitating pre-operative optimization.
- Emphasizes the effectiveness of zinc repletion in resolving deficiency-related symptoms.
Abstract:
Zinc deficiency, though uncommon, can occasionally present in current medical practice. A 4.5-year-old boy with previous gastrointestinal surgery presented with diarrhoea, disinterest and dermatitis affecting the face and perineum. The clinical diagnosis was confirmed by the presence of a low serum zinc level. Administration of parenteral zinc led to rapid improvement in diarrhoea, demeanor and dermatitis. Further surgery was then undertaken, surgery had been postponed until normalisation of zinc levels due the association between zinc deficiency and poor postoperative wound healing.
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