Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A blueprint for local and distal invasion programs in glioblastoma.

Nature communications·2026
Same author

Intercepting YAP Activation in Prostate Cancer Blocks Neuroendocrine Progression.

Cancer research·2026
Same author

Hemp-Derived Extracellular Vesicles: A Novel Frontier in Nanomedicine and Therapeutics.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same author

Non-invasive identification of mesenchymal glioblastoma using quantitative radiomic features from advanced diffusion MRI: a preclinical-to-clinical transfer learning strategy.

European radiology experimental·2025
Same author

Spatial mapping of phosphatidylcholine <i>sn</i>-positional isomers using CID of divalent metal complexes in imaging mass spectrometry.

International journal of mass spectrometry·2025
Same author

The NeuroSphere Assay Applied to Neural Stem Cells and Cancer Stem Cells.

Methods in molecular biology (Clifton, N.J.)·2025
Same journal

Escaping the trap.

Nature reviews. Cancer·2026
Same journal

A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.

Nature reviews. Cancer·2026
Same journal

Systemic health impact of cancer-associated extracellular vesicles and particles.

Nature reviews. Cancer·2026
Same journal

Imaging the hallmarks of cancer.

Nature reviews. Cancer·2026
Same journal

CLIM-TIME links tumour genetics to spatial immune architecture.

Nature reviews. Cancer·2026
Same journal

Serving sulfur to boost anti-tumour immunity.

Nature reviews. Cancer·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

Brain tumour stem cells.

Angelo L Vescovi1, Rossella Galli, Brent A Reynolds

  • 1Department of Biotechnology and Biosciences, University of Milan Bicocca, Milan 20126, Italy. vescovi@tin.it

Nature Reviews. Cancer
|May 26, 2006
PubMed
Summary
This summary is machine-generated.

The adult mammalian brain generates new neurons and glia throughout life. This discovery challenges the old dogma and suggests that disruptions in these neural stem cells may lead to central nervous system (CNS) tumors, offering new therapeutic targets.

More Related Videos

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
12:25

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Published on: January 7, 2014

Related Experiment Videos

Last Updated: May 12, 2026

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
12:25

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Published on: January 7, 2014

Area of Science:

  • Neuroscience
  • Oncology
  • Cell Biology

Background:

  • The traditional view held that new cell generation in the adult brain was minimal, impacting understanding of central nervous system (CNS) tumor development.
  • Recent discoveries reveal continuous production of neurons and glia from neural stem cells throughout adulthood.

Purpose of the Study:

  • To explore the implications of adult neurogenesis for the cellular origins of CNS tumors.
  • To investigate the hypothesis that dysregulation of adult neurogenesis contributes to brain tumorigenesis.
  • To identify novel therapeutic strategies targeting these mechanisms.

Main Methods:

  • Review of existing literature on adult neurogenesis and CNS tumor biology.
  • Analysis of cellular and genetic pathways involved in neural stem cell differentiation and proliferation.
  • Hypothetical modeling of tumorigenesis based on neurogenesis alterations.

Main Results:

  • The continuous generation of neural cells provides a new pool of potential progenitor cells for CNS neoplasms.
  • Alterations in the regulation of adult neurogenesis are hypothesized to play a role in the initiation and progression of brain tumors.
  • This paradigm shift opens avenues for developing targeted therapies for CNS malignancies.

Conclusions:

  • The concept of adult neurogenesis fundamentally changes our understanding of CNS tumor origins.
  • Targeting the mechanisms of adult neurogenesis presents a promising frontier for novel brain cancer therapies.
  • Further research into the interplay between neurogenesis and tumorigenesis is crucial for clinical advancements.