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Sublingual immunotherapy for allergic rhinitis: an update.
1San Raffaele Scientific Institute, Milan, Italy. s.burastero@hsr.it
Summary
Sublingual immunotherapy offers a safe and effective treatment for allergic rhinitis, improving quality of life. Integrating this approach with surgery can optimize outcomes for patients with chronic nasal obstruction.
Area of Science:
- Otorhinolaryngology
- Allergology
- Immunotherapy
Background:
- Allergic rhinitis frequently coexists with nasal diseases, impacting surgical success.
- Sublingual immunotherapy (SLIT) is WHO-recommended for allergic rhinitis, with extensive supporting evidence.
- Optimal integration criteria for SLIT with surgical management of chronic nasal obstruction are not fully established.
Purpose of the Study:
- To review current literature on the efficacy and safety of sublingual immunotherapy.
- To encourage the combined use of SLIT and surgical interventions by ENT specialists and allergologists.
- To enhance the management of patients experiencing persistent allergic rhinitis.
Main Methods:
- Literature review of recent studies on sublingual immunotherapy.
- Analysis of clinical trial data and postmarketing surveillance.
- Evaluation of safety and efficacy in adults and children.
Main Results:
- Sublingual immunotherapy demonstrates a high safety profile and improves quality of life.
- SLIT reduces personal and societal costs associated with allergies.
- It prevents new allergic sensitizations and provides long-lasting benefits.
Conclusions:
- Sublingual immunotherapy is a highly effective and well-tolerated treatment for allergic rhinitis.
- SLIT can modify disease progression and should be combined with surgery for chronic nasal obstruction.
- This integrated approach promises optimal outcomes for allergic patients.