Percutaneous coronary intervention in a patient with von Willebrand's disease presenting with an acute coronary

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Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

John Macdonald1, Manivannan Srinivasan, Ranjit More

  • 1Blackpool Victoria Hospital, United Kingdom.

The Journal of Invasive Cardiology
|May 30, 2006
PubMed

Insights

Managing acute coronary syndromes in patients with von Willebrand disease requires careful consideration of bleeding and clotting risks. This case highlights percutaneous coronary intervention strategies and discusses von Willebrand factor

Area of Science:

  • Cardiology
  • Hematology
  • Vascular Medicine

Background:

  • Optimal management for von Willebrand disease (VWD) patients with acute coronary syndromes (ACS) remains undefined.
  • VWD affects hemostasis due to deficient or dysfunctional von Willebrand factor (VWF).

Observation:

  • A clinical case of successful percutaneous coronary intervention (PCI) post-ACS in a VWD patient is presented.
  • Review of existing literature on VWD, ACS, and interventional cardiology procedures.

Findings:

  • VWF plays a key role in ACS pathophysiology.
  • Low VWF levels may offer potential cardioprotective effects.
  • Balancing hemostasis and antiplatelet therapy is critical in VWD patients undergoing PCI.

Implications:

  • This case and review provide insights into managing VWD patients with ACS.
  • Recommendations for optimizing hemostatic and antithrombotic strategies are suggested.
  • Further research is needed to establish definitive management guidelines.

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