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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Epstein-Barr virus and Hodgkin's lymphoma
1Division of Infectious Diseases and Centre for Infectious Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. jan.andersson@medhs.ki.se
Herpes : the Journal of the IHMF
|May 31, 2006
Summary
Epstein-Barr virus (EBV) is found in nearly half of Hodgkin
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Hodgkin's lymphoma (HL) is a B-cell lymphoproliferative disorder.
- Epstein-Barr virus (EBV) antigens are detected in up to 40% of HL tumors.
- EBV-associated HL patients have higher levels of EBV-infected B-lymphocytes.
Purpose of the Study:
- To characterize EBV antigen expression in Hodgkin/Reed-Sternberg cells.
- To explore EBV's role in HL pathogenesis.
- To investigate potential therapeutic strategies for EBV-positive HL.
Main Methods:
- Analysis of EBV antigen expression patterns (LMP-1, LMP-2, EBNA-1) in tumor cells.
- Comparison of EBV-infected B-lymphocyte levels in blood between HL patients and controls.
- Review of studies on adoptive immunotherapy for refractory EBV-positive HL.
Main Results:
- A restricted pattern of EBV-antigen expression (LMP-1, LMP-2, EBNA-1) is characteristic of tumor cells.
- Elevated EBV-infected B-lymphocytes are observed in EBV-associated HL.
- Adoptive T-cell immunotherapy is being investigated for EBV-positive HL.
Conclusions:
- EBV plays a significant role in a subset of Hodgkin's lymphoma cases.
- Specific EBV antigens are uniquely expressed in HL tumor cells.
- The etiology of non-EBV-associated HL requires further investigation.
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